Ketamine, classified as a synthetic anesthetic within the dissociative category, showcases a multifaceted range of effects dictated primarily by its dosage. While it frequently finds use in smaller doses as a recreational substance, higher doses can usher individuals into profound, psychedelic states commonly known as the “K-Hole.” Beyond recreational settings, the field of psychiatry has embraced ketamine as a rapid-acting antidepressant, particularly beneficial for individuals grappling with treatment-resistant depression.

Effects of ketamine:

Ketamine’s impact is intrinsically tied to the quantity consumed. Lower doses generate sensations akin to disinhibition and relaxation, often reminiscent of the effects of alcohol. Conversely, higher doses can transport users into trance-like realms or even facilitate out-of-body experiences. In these heightened states, reality might fracture, sensory perceptions undergo radical shifts, and individuals may feel weightless, as if floating. At the zenith of dosage, some might even experience detachment from their physical form, fusion with the surroundings, or a dissolution of the ego. Post-trip, it’s common to encounter drowsiness, with memory fragments from the journey.

Duration:

• Onset of Action:
  • Snorted: 5 – 10 minutes
  • Swallowed: 15 – 20 minutes
  • Injected intramuscularly: 2 – 5 minutes
  • Injected intravenously: within seconds
• Duration of Effect: Typically lasts 45 minutes to 2 hours, contingent on the dose and mode of ingestion.

Dosage:

Ketamine’s dosage hinges on the desired outcome. In recreational scenarios, users often insufflate a few milligrams to achieve their preferred effects. While higher dosages can amplify the experience, they are not advisable for recreational purposes.

• When snorted:
  • Light: 10 – 30 mg
  • Medium: 30 – 75 mg
  • Strong: 75 – 150 mg
• When swallowed:
  • Light: 50 – 100 mg
  • Medium: 100 – 300 mg
  • Strong: 300 – 450 mg
• When injected intramuscularly: 70 – 150 mg
• When injected intravenously: Approximately 50 mg

Appearances: Ketamine manifests in diverse forms, encompassing white crystalline powder or “sticks,” and on rarer occasions, as a liquid solution.

Risks:

The use of ketamine can lead to restricted mobility and communication, insensitivity to pain, coordination troubles, a sense of weakness, loss of appetite, bouts of nausea, vomiting, muscular tremors, dizziness, slurred speech, elevated heart rate, and cardiac arrhythmias. Elevated doses might result in muscle rigidity, paralysis, states of narcosis, seizures, or even coma. Ketamine can exert strain on the cardiovascular system and trigger psychological distress, including near-death experiences, hallucinations, and memory gaps.

Ketamine Long-term Risks:

Prolonged ketamine use can pave the way for psychological dependence and cause harm to vital organs such as the liver, bladder, and kidneys. Additionally, it can be associated with persistent feelings of depression and anxiety, and it’s suspected to impact memory, learning, and cognitive faculties.

Guidelines for Safe Use:

• When opting for ketamine use, it’s wise to avoid high doses when alone. Ensuring a familiar and comfortable environment is pivotal, and allocating time for reflection post-trip is prudent.
• Approach dosing with care, as minor deviations in dosage can lead to substantial variations in effects.
• Intermittent breaks from use can help stave off psychological dependence.
• Having a secure space to sit or lie down, especially when dealing with high doses, is crucial due to insensitivity to pain.
• It’s imperative to be mindful of avoiding self-injury, given the numbness to pain.
• To mitigate nausea, it’s advisable not to consume ketamine on a full stomach.
• Those with cardiovascular issues, high blood pressure, or glaucoma should refrain from ketamine use.

Mixed Use of Ketamine:

• Combining ketamine with alcohol, GHB/GBL, benzodiazepines, or opiates is perilous, as it heightens the risk of respiratory arrest.
• Mixing ketamine with stimulants like amphetamines or cocaine can lead to circulatory issues, heightened heart rate, and respiratory distress.

Sexual Behavior:

Ketamine’s narcotic influence, coupled with its propensity to distort reality, might contribute to increased risk-taking during sexual encounters.

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